Dna

Researchers take closer look at DNA repair scheme for cancer therapy

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, have taken a closer look at one of the ways cells repair broken strands of DNA.They discovered details that could help make a particular enzyme a promising target for precision cancer therapy.Not unlike patching a tire, the job of DNA polymerase theta (aka Pol theta) is to fix double-strand breaks in DNA, bridging the hanging single-stranded ends and catalyzing DNA synthesis across the break, a process known as microhomology-mediated end joining (MMEJ).MMEJ is complementary to two other processes -- homologous recombination and non-homologous end joining -- that repair DNA double-strand breaks, but with lower fidelity because Pol theta is prone to mutation, insertion, and deletion errors.But therein lies the advantage: MMEJ needs Pol theta to repair a double strand.A new study by Rice and St. Jude's researchers in the journal Nucleic Acids Research reveals for the first time the ...

Noise launches Air Buds 2 wireless earbuds at Rs 1,799: Know specs and more

The Noise Air Buds 2 will be available in clear white and clear black colours on Noise's official website, Amazon, and Flipkart from November 24

300-year-old system of naming bacteria revised on scientific advances

A new way to name bacteria: 300-year-old system revised thanks to scientific advances

Ancient viral DNA in human genome protects against infections: Research

According to new research, viral DNA embedded in human genomes from ancient infections acts as antivirals, protecting human cells from certain modern viruses.The paper "Evolution and Antiviral Activity of a Human Protein of Retroviral Origin," published in the journal Science, demonstrates the effect in principle.Previous research has shown that endogenous retroviruses, fragments of ancient viral DNA found in the genomes of mice, chickens, cats, and sheep, provide immunity against modern viruses that originate outside the body by preventing them from entering host cells. Despite the fact that this research was done on human cells in culture, it shows that endogenous retroviruses have an antiviral effect on humans.The study is significant because it could discover a pool of natural antiviral proteins that could lead to treatments without autoimmune side effects. The research suggests the existence of a genome defence system that has yet to be identified but could be quite ...

Nobel Prize win for Swede who unlocked secrets of Neanderthal DNA

Swedish scientist Svante Paabo won the Nobel Prize in medicine Monday for discoveries on human evolution that unlocked secrets of Neanderthal DNA that helped us understand what makes humans unique and provided key insights into our immune system, including our vulnerability to severe COVID-19. Techniques that Paabo spearheaded allowed researchers to compare the genome of modern humans and that of other hominins the Denisovans as well as Neanderthals. Just as you do an archeological excavation to find out about the past, we sort of make excavations in the human genome, he said at a news conference held by Max Planck Institute for Evolutionary Anthropology in Leipzig. While Neanderthal bones were first discovered in the mid-19th century, only by understanding their DNA often referred to as the code of life have scientists been able to fully understand the links between species. This included the time when modern humans and Neanderthals diverged as a species, around 800,000 years a

Mitochondrial DNA mutations associated with heart disease risk: Research

During a recent study researchers have discovered how mitochondrial function, and dysfunction, play critical roles in numerous diseases, and even ageing.

Humans decoded

It's expected that genome-based research will help develop highly effective diagnostic tools and treatments for diseases

How the human code has been unraveled: Here's what experts suggest

Last week, scientists completed sequencing the human genome, the goal of a project that began in October 1990

Rethink the Bill

The criminal procedure law erodes fundamental rights

Corona epidemic hit 20K years ago, could alter people's DNA, says study

May have dire implications if Covid-19 not brought under control soon

LosJovenes Clinilogic: understanding the company's "DNA"

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World's oldest DNA sheds light on how mammoths evolved: Study

Scientists have sequenced the world's oldest DNA recovered from the remains of mammoths

Covid-19 crisis: Race to develop vaccine gets a booster as field widens

On Thursday, CDSCO also approved Zydus Cadila's plasmid DNA vaccine candidate ZyCoV-D, developed at its Vaccine Technology Centre in Ahmedabad.

Cancer drug with new process on slowing DNA repair shows promise in trial

The clinical trial led by investigators at the Dana-Farber Cancer Institute was detailed in the journal The Lancet Oncology

Breakthrough in dealing with snakebite

The sequencing of the genome of the Indian cobra could soon lead to improvements in the techniques used for producing anti-venom

Should you eat your rice or ditch it? Let your genes choose for you

Look at the people from other South-East Asian countries where rice is more a staple than in India. How many of them are overweight or obese?

DNA gets a new - and bigger - genetic alphabet

Hachimoji DNA could be a far more durable way to store digital data that could last for centuries

There's no law around genetic code, but DNA is being used in many ways

The genetic code is being used in many ways - from investigating crime to drawing up a personalised diet plan, tracing one's ancestry and even as artwork

What our DNA foretells

The book is brilliantly lucid in its explanations of methodology, and specific studies. It's written from a standpoint of humility.

DNA: Between crime busting and privacy

India has a proposal that would make it mandatory for anybody making a police complaint to provide a DNA sample