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Pfizer will spend USD 43 billion to buy Seagen and deepen its reach into treating cancer. The pharmaceutical giant said Monday that it will pay USD 229 per Seagen share. Together, Pfizer and Seagen seek to accelerate the next generation of cancer breakthroughs and bring new solutions to patients by combining the power of Seagen's antibody-drug conjugate (ADC) technology with the scale and strength of Pfizer's capabilities and expertise," Pfizer Chairman and CEO Dr. Albert Bourla said in a statement. Bothell, Washington-based Seagen Inc. is a biotech drug developer. Its key products use monoclonal antibodies that bind to the surface of a tumour cell to deliver a cancer-killing agent while sparing surrounding healthy tissue. Monoclonal antibodies are lab-made proteins delivered mostly by IV at an infusion center, according to the Cleveland Clinic. Seagen's top seller, Adcetris, treats lymph system cancers. It brought in USD 839 million in sales last year, a 19 per cent increase over
Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, have taken a closer look at one of the ways cells repair broken strands of DNA.They discovered details that could help make a particular enzyme a promising target for precision cancer therapy.Not unlike patching a tire, the job of DNA polymerase theta (aka Pol theta) is to fix double-strand breaks in DNA, bridging the hanging single-stranded ends and catalyzing DNA synthesis across the break, a process known as microhomology-mediated end joining (MMEJ).MMEJ is complementary to two other processes -- homologous recombination and non-homologous end joining -- that repair DNA double-strand breaks, but with lower fidelity because Pol theta is prone to mutation, insertion, and deletion errors.But therein lies the advantage: MMEJ needs Pol theta to repair a double strand.A new study by Rice and St. Jude's researchers in the journal Nucleic Acids Research reveals for the first time the ...
Tennis great Martina Navratilova said on Monday that she has been diagnosed with throat cancer and breast cancer. In a statement released by her representative, the 18-time Grand Slam singles champion and member of the International Tennis Hall of Fame said her prognosis is good and she will start treatment this month. "This double whammy is serious but still fixable, and I'm hoping for a favourable outcome," the 66-year-old Navratilova said. "It's going to stink for a while but I'll fight with all have I got." She said she noticed an enlarged lymph node in her neck while attending the season-ending WTA Finals in Fort Worth, Texas, in November, and a biopsy showed early stage throat cancer. While Navratilova was undergoing tests on her throat, she said, the unrelated breast cancer was discovered. Navratilova was diagnosed with a noninvasive form of breast cancer in 2010 and had a lumpectomy. She won 59 Grand Slam titles overall, including 31 in women's doubles and 10 in mixed dou
Estimated cancer cases and mortality due to it have increased in the country between 2020 and 2022, Union Health Minister Mansukh Mandaviya told the Rajya Sabha on Tuesday, citing official data. The Department of Health and Family Welfare provides technical and financial support to states and Union territories under the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS) as part of the National Health Mission (NHM), based on the proposals received from the states and subject to the resource envelope, he said in reply to a question. According to the National Cancer Registry Programme of the Indian Council of Medical Research (ICMR), an estimated incidence of cancer cases in India by different states and Union territories in 2020 was 13,92,179 and it increased to 14,26,447 in 2021 and 14,61,427 in 2022. Estimated mortality due to cancer in India was 7,70,230 in 2020 and it increased to 7,89,202 in 2021 and 8,08,558 in 2022, ..
The estimated number of cancer cases in the country in 2020 was 13,92,179 and it is projected to increase by 12.8 per cent, Union Health Minister Mansukh Mandaviya informed Lok Sabha on Friday citing National Cancer Registry Programme data. Responding to a question, Mandaviya said patients with cancer are getting treatment at various health facilities, including district hospitals, medical colleges, central institutes like AIIMS and private hospitals. Relevant data related to patients registered for treatment is maintained by the institutions and hospitals concerned at their own level. Under the Rashtriya Arogya Nidhi (RAN), financial assistance is provided to poor patients belonging to families living below poverty line, suffering from major life threatening diseases for medical treatment at any of the super specialty hospitals/institutes or other government hospitals, Mandaviya said. Under the Health Minister's Cancer Patient Fund (a component of RAN), Rs 216. 98 lakh was utilised
Cancer screenings and treatment were affected due to Covid but the screening services have gone up post-pandemic, Union Minister of State for Health Bharti Pawar informed Lok Sabha on Friday. Replying to a supplementary question in the Lok Sabha during Question Hour, she said the government is focusing on increasing screenings and early detection of cancer. "Due to Covid, cancer screenings and treatment were affected. After Covid, screenings have increased," Pawar said. She said cancer screening services are being provided through 1.5 lakh Health and Wellness Centres (HWC) across the country. Through these HWCs, 16 crore cases of oral cancer, eight crore cases of breast cancer and around 5.53 crore cases of cervical cancer have been detected, the minister said. "Whether it is rural or urban areas, these services need to be increased. In that view, we are going to increase our 1.5 lakh HWCs throughout the country and through that, we are providing very good screening services," she