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Pharmaceuticals firm Lupin Ltd on Thursday said its US-based arm is recalling four lots of Quinapril tablets used to treat high blood pressure due to the presence of a nitrosamine impurity. Lupin Pharmaceuticals Inc, the company's wholly-owned arm, is recalling the said tablets due to the presence of a nitrosamine impurity, N-Nitroso-Quinapril, observed in recent testing above the acceptable daily intake (ADI) level, Lupin Ltd said in a regulatory filing. "To date, Lupin has received no reports of illness that appear to relate to this issue," it said, adding it discontinued marketing of Quinapril tablets in September 2022. Quinapril tablets of strengths 20mg and 40mg packaged in separate 90 count bottles were distributed nationwide in the US to wholesalers, drug chains, mail order pharmacies and supermarkets, it added. The filing further said Lupin Pharmaceuticals Inc is notifying its wholesalers, distributors, drug chains, mail order pharmacies and supermarkets by phone and throug
Increasing numbers of children have high blood pressure, largely as a consequence of their obesity. A growing body of evidence suggests that high blood pressure may impair children's cognitive skills, reducing their ability to remember, pay attention and organise facts.In the most comprehensive study to date, published on Thursday in The Journal of Pediatrics, 75 children ages 10 to 18 with untreated high blood pressure performed worse on several tests of cognitive function, compared with 75 peers who had normal blood pressure.The differences were subtle, and the new research does not prove that high blood pressure diminishes cognitive skills in children. Still, the findings set off alarm bells among some experts. "This study really shows there are some differences," said David B Kershaw, the director of pediatric nephrology at C S Mott Children's Hospital at the University of Michigan, who was not involved with the research. "This was not just random chance."Marc B Lande, a professor