The turmoil has, in turn, upended a lucrative revenue stream for investment banks, whose results are also facing tough year-earlier comparisons when accommodative monetary policies led to record levels of deals.
Revenue from investment banking plunged 55% to $1.1 billion, with the bank's advisory business taking a 10% hit. Equity and fixed income underwriting revenue also plunged 86% and 49%, respectively.
JPMorgan Chase & Co reported a 61% drop in investment banking revenue.
Morgan Stanley's wealth management business, which is seen as a durable source of revenue, did little in the quarter to offset the slump in dealmaking.
Revenue from the business dipped 6% and contributed to a 11% slide in Morgan Stanley's net revenue and a 30% drop in profit.
Morgan Stanley also said it had recorded a $200 million expense related to a regulatory matter tied to the use of unapproved personal devices and record-keeping requirements.
The bank reported a profit of $2.4 billion, or $1.39 per share, for the quarter ended June 30, compared with $3.4 billion, or $1.85 per share, a year earlier.
Analysts on average had expected a profit of $1.53 per share, according to data from Refinitiv.
Shares of the bank were down 1.2% in premarket trade, after dropping nearly 23.6% this year as of last close.